Hypoglycaemia, stress, elderly. Thyroid impairment, monitor blood-glucose conc and renal function regularly.
Adult: PO Per tab contains glipizide 2.5 mg and metformin 250 mg. As initial therapy: Start w/ 1 tab once daily. May increase slowly to lowest effective dose to a max of 4 tab/day in divided doses.
For patients previously treated w/ glibenclamide/sulphonylurea or metformin alone: Recommended starting dose: 2 tab twice daily; starting dose should not exceed the daily doses of glipizide or metformin already being taken.
Titrate subsequent doses based on blood glucose levels and patient’s response. Daily max: 20 mg glipizide/2000 mg metformin.